组蛋白的甲基化、乙酰化和磷酸基化等翻译后修饰(PTM)是调节基因表达调控、DNA修复、染色体凝缩和精子形成的关键步骤。目前,已经确认许多蛋白能够形成复合物,起到调节组蛋白修饰的作用。 这些组蛋白修饰复合物的功能变化被认为破坏了组蛋白标记的结构和水平,从而解除了基于核染色质的过程控制,最终导致致癌转化和癌症的发展。与此一致的是,组蛋白PTM的异常模式与大量的人类恶性肿瘤有关。
众所周知,组蛋白的翻译后修饰(PTM)在表观遗传调控中发挥重要作用,研究组蛋白PTM过程中抗体是很重要的一环,组蛋白PTM的抗体是表观遗传学研究(如染色质免疫沉淀(ChIP)、免疫染色和免疫印迹)中的关键元素。然而,目前市面上许多组蛋白PTM抗体不能特异识别预定目标。今天小艾给大家带来知名品牌Rockland专利的组蛋白修饰相关抗体——Epi-Plus系列抗体,期望Epi-Plus凭借其无与伦比灵敏度和特异性给广大科研工作者组蛋白PTM研究带来新助力。
Rockland Epi-Plus特点及优势:
Rockland的高特异性Epi-Plus系列抗体可识别经过修饰的组蛋白和相关的细胞靶点,并通过多种检测方法进行验证。Epi-Plus抗体对这种修饰是特别灵敏和特异的,并且对相同位点或该蛋白其他氨基酸的其他修饰没有交叉反应。免疫荧光(IF)、免疫沉淀(IP)、染色质免疫沉淀(ChIP)、免疫组化(IHC)和蛋白印迹(WB)的分析验证了Epi-Plus抗体的有效性。
Histone 3 K4 甲基化相关抗体:
货号 | 名称 | 规格 |
600-401-I57 | Anti-Histone H3 [Monomethyl Lys4] (RABBIT) Antibody | 50ug |
600-401-I58 | Anti-Histone H3 [Dimethyl Lys4] (RABBIT) Antibody | 50ug |
600-401-I59 | Anti-Histone H3 [Trimethyl Lys4] (RABBIT) Antibody | 50ug |
Epi-Plus?其他组蛋白修饰抗体推荐:
货号 | 名称 | 规格 | 种属反应 |
600-401-I52 | Histone H3 R2me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I53 | Histone H3 R2me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I54 | Histone H3 K4me1/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I55 | Histone H3 K4me2/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I56 | Histone H3 pT3/K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I57 | Histone H3 K4me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I58 | Histone H3 K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I59 | Histone H3 K4me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I60 | Histone H3 K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I61 | Histone H3 K4me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I62 | Histone H3 K4me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I63 | Histone H3 pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I64 | Histone H3 K9me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I65 | Histone H3 K9me2/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I66 | Histone H3 K9me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I67 | Histone H3 R8me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I68 | Histone H3 R8me2s Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I69 | Histone H3 K9me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I70 | Histone H3 K9me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I71 | Histone H3 K9me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I72 | Histone H3 K9ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I73 | Histone H3 K9ac/K14ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I74 | Histone H3 pS10 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I75 | Histone H3 pS10/pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I76 | Histone H3 pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I77 | Histone H3 R17me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I78 | Histone H3 K18me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I79 | Histone H3 K18me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I80 | Histone H3 K18me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I81 | Histone H3 K18ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I82 | Histone H3 K23ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I83 | Histone H3 pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I84 | Histone H3 K27me3/pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I85 | Histone H3 R2me2s/K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I86 | Histone H3 K36me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I87 | Histone H3 K36me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I88 | Histone H3 K36me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I89 | Histone H3 K36ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I90 | Histone H3 K37me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I91 | Histone H3 K37me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I92 | Histone H3 K37me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I93 | Histone H3 K56me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I94 | Histone H3 K56me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I95 | Histone H3 K79Me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-J98 | Histone H3 K4-Me3/K9-Ac Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-J99 | Histone H3 K27me3 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K00 | Histone H3 K27ac Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K01 | Histone H3 K4me2/pT6 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K02 | Histone H3 K23me2 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-M75 | Histone H3 K27 methyl Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-P08 | Histone H3 K9-Ac/pS10 (RABBIT) Antibody | 50ug | Human |
600-401-P10 | Histone H3 K79-Me1 Antibody | 50ug | Human, Mouse, Primate, C. elegans, Drosophila, Plant, Rat, Xenopus |
600-401-P14 | Histone H3 pT3/R2-Me2s Antibody | 50ug | Human |
600-401-V34 | Histone H3 K27 me2 Antibody | 50ug | Human |
600-401-W54 | Histone H3 K27 me1 Antibody | 50ug | Human |
*以上产品仅供科研使用,不得用于医疗及诊断.
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